不同证型老年男性高血压病患者性激素相关调控因素的比较研究

Comparative Study on Sex Hormones Related Regulating Factors of Elder Men with Hypertension of Different Syndromes

目的:探讨男性老年人高血压病肾气亏虚证、肝火上炎证与性激素相关调控因素的关联性,从而为研究老年人高血压病肾气亏虚证、肝火上炎证证候表现的病理生理基础提供依据。方法:根据高血压诊断与分级标准、中医辨证标准选择了男性高血压病肾气亏虚证、肝火上炎证患者各30例和健康老年男性30例,采用酶联免疫吸附法检测白介素-2(IL-2)、瘦素(Leptin)、肿瘤坏死因子(TNF-α)、促性腺激素释放激素(GnRH)和硫酸脱氢表雄酮(DHEA-S)的水平。结果:男性老年人高血压肾气亏虚证患者的性激素相关调控因素水平的异常变化与男性老年人高血压病肾气亏虚证的发病有关,预示血清白介素-2、瘦素、促性腺激素释放激素和硫酸脱氢表雄酮水平的异常变化可能是男性老年人高血压病肾气亏虚证形成的病理基础之一。

Objective：This paper studies the relationship between sex hormones related regulating factors and elderly male with hypertension of kidney deficiency syndrome and liver fire upflaming syndrome,so as to provide basis for study on pathophysiological changes of kidney deficiency syndrome of hypertension and liver fire upflaming syndrome of hypertension.Methods：According to hypertension diagnosis and classification standard,TCM differentiation standard chose elder male with hypertension of kidney deficiency syndrome（30 cases）and liver fire upflaming（30 cases）and healthy elderly men（30 cases）.The Elisa method was used to detect IL-2,Leptin,TNF-α,GnRH and DHEA-S levels.Results：Abnormal changes of sex hormones related regulating factors levels of elderly male patients with hypertension of kidney deficiency syndrome had relevant with kidney deficiency.That indicated abnormal changes of IL-2,Leptin and GnRH and DHEA-S levels may be one of the mechanism of kidney deficiency syndrome of hypertension in elder male patients.