高血压不同并发症患者CRP、IL-6水平变化及血脂康干预的疗效观察

Observation on the Intervention Efficacy of Xuezhikang Capsule on Levels of CRP and IL-6 in Hypertension Patients with Different Complications

目的:观察原发性高血压(EH)不同合并症患者体内炎症反应的程度与中药血脂康的干预疗效。方法:观察EH患者120例,根据其合并症的不同,分为单纯EH组30例,EH合并心房颤动(EH-AF)组30例,EH合并腔隙性脑梗死(EH-LI)组30例,EH合并左心室肥厚(EH-LVH)组30例,同时选择30例健康体检者作为对照组。每组EH患者随机又分为两个亚组,即常规治疗亚组(主要运用钙拮抗剂ACEI、ARB、利尿剂、β受体阻断剂等药物治疗8周)和血脂康干预亚组(常规治疗加血脂康1.2g/d)。药物治疗前后检测血hs-CRP、IL-6水平。结果:(1)所有入选EH患者的hs-CRP、IL-6水平显著高于正常对照组(P<0.05);(2)EH-AF组、EH-LI组、EH-LVH组的hs-CRP、IL-6水平无明显差异(P>0.05),但均显著高于单纯EH组(P<0.05);(3)血脂康组和常规治疗组治疗后,其hs-CRP、IL-6水平均显著下降(P<0.05),两组间比较,血脂康组明显更优(P<0.05);(4)血脂康组和常规治疗组治疗后,其血压均显著下降(P<0.05),两组间比较,血脂康组的血压下降幅度更加显著(P<0.05)。结论:炎症反应指标hs-CRP、IL-6的上升与EH并发症的产生关系密切,血脂康能够显著下调EH患者的hs-CRP、IL-6和血压水平,提示联合应用降压药物和血脂康对于EH患者可能更为有益。

Objective：To observe the extent of inflammatory response in vivo in essential hypertension（EH）patients with different complications,and the intervention efficacy of Xuezhikang capsule.Methods：120 patients with EH were divided into 4 groups according to different complications：the EH group（n=30）,the EH with atrial fibrillation（EH-AF）group（n=30）,the EH with lacunar infarction（EH-LI）group（n=30）and the EH with left ventricular hypertrophy（EH-LVH）group（n=30）.Meanwhile,30 healthy subjects were served as the control group.The each group of EH patients were randomly divided into the conventional treatment subgroup（calcium antagonists,ACE inhibitors,ARB,diuretics and beta-blocker treatment for 8 weeks）and the Xuezhikang intervention subgroup（Xuezhikang capsule,1.2g/d,and conventional treatment for 8 weeks）.The levels of serum hs-CRP and IL-6 were determined before and 8 weeks after the treatment.Results：（1）The levels of hs-CRP and IL-6 in EH,EH-AF,EH-LI and EH-LVH groups were superior to that in control group（P〈0.05）.（2）There was no statistically significant difference among the four groups with EH（P〈0.05）.（3）After 8 weeks of treatment,the levels of hs-CRP and IL-6 decreased（P〈0.05）,and the efficacy of Xuezhikang intervention subgroup was superior to that of conventional treatment subgroup（P〈0.05）.（4）Similarly,the levels of blood pressure decreased after treatment（P〈0.05）,and the efficacy of Xuezhikang intervention subgroup was also superior to that of conventional treatment subgroup（P〈0.05）.Conclusion：The indicators of inflammatory response such as hs-CRP and IL-6 have a close relationship with EH complications.Xuezhikang could markedly decrease the levels of hs-CRP and IL-6 and blood pressure.It is prompted us that the joint application of antihypertensive drugs and Xuezhikang may be more useful to EH patients.