右美托咪啶对老年患者腹腔镜下宫颈癌根治术后早期认知功能的影响

Effects of dexmedetomidine on postoperative cognitive dysfunction in elderly patients undergoing iaparo- scopic radical trachelectomy

目的评价右美托咪啶对老年患者腹腔镜下宫颈癌根治术后早期认知功能的影响。方法择期腹腔镜下宫颈癌根治术患者60例，ASA分级I或Ⅱ级，年龄65～80岁，体重55～74k，采用随机数字表法，将其随机分为2组（n=30）：生理盐水组（NS组）和右美托眯啶组（DEX组）。麻醉诱导后DEX组静脉输注右美托咪啶0．2μg·kg^-1·h^-1，NS组给予等容量生理盐水，术毕静脉注射芬太尼0．5μg／kg，并停止给予麻醉药物。分别于术前1d和术后7d对患者进行认知功能测验。结果DEX组术后7d时认知功能障碍发生率低于NS组（P〈0．05）。结论右美托咪啶可降低老年患者腹腔镜下宫颈癌根治术后早期认知功能障碍的发生。

Objective To investigate the effects of dexmedetomidine on postoperative cognitive dysfunction （POCD） in the elderly patients undergoing laparoscopic radical trachelectomy.nethods Sixty ASA I or II patients （aged 65-80 yr and weighing 55-74 kg） undergoing elective laparoscopic radical trachelectomy were randomly divided into two groups ： 30 patients received intravenous injection of dexmedetomidine 0.2μg· kg^- 1· h -^ 1（ group D EX） and 30 received same volume of normal saline （control group, group NS） after induction of anesthesia. Cognitive function was assessed at 1 day before operation and on the 7th day after operation using a battery of nine cog- nitive dysfunction tests. Results Compared with group NS, on the 7th postoperative day, the incidence of POCD was decreased in group DEX （ P 〈 0.05 ）. Conclusion Dexmedetomidine can improve POCD in the elderly pa- tients undergoing laparoscopic radical trachelectomy.