母亲妊娠期高血压病新生儿脐血食欲素与生长激素、瘦素的关系

Relationships between Cord Blood Orexin and Growth Hormone,Leptin of Neonates Whose Mothers Have Hypertensive Disorder in Pregnancy

目的探讨妊娠期高血压病(HDP)对其新生儿脐血食欲素水平的影响及食欲素与生长激素(GH)、瘦素的关系。方法选取HDP母亲所生新生儿65例,依HDP诊断标准将其分为3组:HDP组(HDP1组)24例、子前期轻度组(HDP2组)23例、子前期重度组(HDP3组)18例。另选41例孕母体健的新生儿为健康对照组。采用放射免疫分析法测定各组脐血食欲素、GH、瘦素水平,并分析食欲素与GH、瘦素的相关性。结果 1.HDP各组新生儿脐血食欲素水平均高于健康对照组,且随母亲HDP程度加重逐渐升高,组间比较差异有统计学意义(F=3.962,P<0.05)。2.HDP各组新生儿脐血GH水平均高于健康对照组,且随母亲HDP程度加重逐渐升高,组间比较差异有统计学意义(F=4.839,P<0.05)。3.HDP各组新生儿脐血瘦素水平均低于健康对照组,且随母亲HDP程度加重逐渐降低,组间比较差异有统计学意义(F=2.678,P<0.05)。4.HDP各组新生儿脐血食欲素水平与GH水平呈正相关,而与瘦素水平呈负相关(r=0.323、-0.297,Pa<0.05)。结论 HDP影响了胎儿内分泌代谢的调节,且影响程度与HDP的临床进程有一定关系;食欲素可能参与创伤应激后内环境紊乱的调控。

Objective To investigate the influence of hypertensive disorder in pregnancy （HDP） on the orexin level of the cord blood and analyze the relationship between orexin level and growth hormone （GH） level, leptin level. Methods Sixty - five neonates whose mothers had HDP were involved in the research. They were divided into 3 groups ： gestational hypertension group（ HDP1 group, n = 24） , mild pre - eclamp- sia group（ HDP2 group,n = 23 ） and severe pre- eclampsia group（ HDP3 group,n = 18）. Forty- one neonates whose mothers were health in pregnancy were involved in normal control group. The orexin, GH and leptin levels in cord blood were measured by radioimmunoassay. Results 1. Orexin level of the cord blood in HDP groups were higher than that in normal control group, and they increased gradually with the severity of the mothers＇s HDP,there were significant differences among the 4 groups （F = 3. 962, P 〈 0.05 ）. 2. GH level of the cord blood in HDP groups were higher than that in normal control group, and they increased gradually with grades of the mothers＇s HDP, there were significant differences among the 4 groups（ F = 4. 839 ,P 〈 0.05 ）. 3. Leptin level in HDP groups were lower Jahan that in normal control group, and they decreased gradually with grades of the mother＇s HDP, there were statistically significant differences among the 4 groups （ F = 2. 678, P 〈 0.05 ）. 4. Orexin level had positive correlation with Gld（ r = 0. 323, P 〈 0.05 ）, but had negative relationship with leptin（ r = - 0. 297, P 〈 0.05 ）. Conclusions Disbennifit uterus conditions of HDP may affect the regulation of fetus＇s incretion, and the affection has a relationship with the nroress of HDP. Orexin may take oart in regulation of inner environmental disorder which traumatic irritability lead.