中期因子与Ki67在大肠癌中的表达及其临床意义

Expression and clinical significance of midrine and Ki67 in patients with colorectal carcinoma

目的研究结大肠癌中中期因子（MK）和Ki67的表达及其与临床病理学特征关系。方法应用免疫组织化学方法检测62例大肠癌组织及20例大肠癌癌旁组织中MK、Ki67表达水平。结果MK、Ki67表达在大肠癌组织中均显著高于癌旁正常组织（P〈0．05）；大肠癌组织MK、Ki67表达与浸润深度、淋巴结转移、Dukes’分期呈正相关（P〈0．05）；MK与Ki67表达呈正相关性（P〈0．05）。结论MK、Ki67在大肠癌组织中高表达，两者在大肠癌的肿瘤生成和进展中起重要作用。

Objective To investigate the expression of midkine （MK）, Ki67 in patients with colorectal carcinoma, and the relationship between the expression and clinicopatheological features. Methods The expressions of MK and Ki67 in 62 cases of colorectal carcinoma tissues, 20 cases of adja- cent normal tissues were detectecl by immunohistochemistry. Results The expressions of MK and Ki67 were significantly higher in colorectal carcinoma than those in adjacent normal colorectal tissues （ P 〈 0. 05 ）. MK and Ki67 expressions were positively correlated with invasion depth, lymph node metastasis and Dukes＇ stage （ P 〈 0. 05 ）. A positive correlation was found between MK and Ki67 expressions （P 〈 0.05 ）. Conclusions There are high expressions of MK and Ki67 in colorectal carcinoma, indicating that MK and Ki67 play an important role in promoting tumor angiogenesis and progression of colorectal carcinoma.