贝前列素钠对老年2型糖尿病肾病患者FN及UAER的影响

Effects of beraprost sodium on plasma FN and UAER in patients with diabetic nephropathy

目的观察贝前列素钠对老年2型糖尿病肾病（DN）患者的临床疗效，并观察患者血浆纤维蛋白原（FN）及尿白蛋白排泄率（UAER）的变化。方法测定27例老年2型无肾病糖尿病患者、48例老年2型临床糖尿病肾病患者血浆FN水平。将48例老年2型糖尿病肾病患者随机分为常规治疗组24例和贝前列素钠治疗组24例，观察两组治疗前后FN、UAER的变化。结果老年2型糖尿病肾病患者较老年2型无肾病糖尿病患者血浆FN水平明显升高（P〈0．01）；与对照组比较，应用贝前列素钠可使糖尿病肾病患者血浆FN水平明显降低（P〈0．01），UAER明显降低（P〈0．05）。结论FN水平升高在糖尿病’肾病的发病中发挥重要作用。贝前列素钠治疗可纠正糖尿病肾病患者血浆FN平衡失调，减少UAER，促进病情恢复。

Objective To observe the clinical tients with type 2 diabetic nephropathy （ DN）, and to and urinary albumin excretion rate（UAER）. Methods curative effect of beraprost sodium on elderly paobserve the changes of plasma fibrinogen （FN） The plasma FN levels of 27 senile type 2 diabe- tes patients without nephropathy, 48 elderly patients with type 2 diabetic nephropathy were measured. Forty-eight cases of elderly patients with type 2 diabetic nephropathy were divided into two groups, the conventional treatment group （24 cases） and beraprost sodium treatment group （24 cases） , the changes of levels of FN and UAER in the two groups before and after treatment were observed. Results The plasma FN levels in the elderly patients with type 2 diabetic nephropathy were significantly elevated than those in elderly patients with type 2 diabetes without nephropathy （ P 〈 0. 01 ）. Compared with the con- trol group, the plasma levels of FN and UAER were significantly reduced in patients with type 2 diabetic nephropathy by beraprost sodium （ P 〈 0.05）. Conclusions The level of FN increase at the onset of diabetic nephropathy and play an important role in the pathogenesis of diabetic nephropathy. Bera- prost sodium in treatment of patients with diabetic nephropathy can correct the plasma FN imbalance, and it can reduce UAER and promote recovery.