双1,3,4-噻二唑基取代脲的合成及其生物活性研究

Synthesis and biological activity of bis-thiadiazlo-2-yl-ureas

用2-氨基-5-巯基-1,3,4-噻二唑与1,3-二溴丙烷和一系列叠氮化合物反应,合成了7种未见文献报道的双1,3,4-噻二唑基取代脲类化合物,并用元素分析、红外光谱、质谱和核磁共振氢谱对化合物进行了表征,生物活性实验证明,该类化合物10mg/L表现出较好的生长素活性和细胞分裂素活性。其中化合物a、b的细胞分裂素活性最好,其活性达到39%。

Seven new bis-thiadiazloe-ureas derived from 2-amino-5-mercapto-1,3,4-thiadiazole,1,3-dibromopropane and acyl azides were synthesized and characterized by their physical constants,elementary analysis,IR,MS and 1HNMR.The results of biological activity tests showed that they all had activity on plant growth hormone and auxin at the concentration of 10mg/L,Where the promoting of a and b reached 39%.