牛血清蛋白催化Michael-Aldol串联反应的研究

BSA-catalyzed Michael-aldol cascade reaction

首次报道了牛血清蛋白(BSA)催化二苯甲酰甲烷和丁烯酮的Michael-Aldol串联反应,并对1,3-二羰基化合物进行了研究,丁烯酮与α,β-不饱和酮酯化合物只生成一分子Michael及双分子Michael加成产物,该方法为合成环状化合物提供了新的途径。

Bovine serum albumin（BSA）was able to catalyse Michael-Aldol cascade reaction between MVK and dibenzoyl methane.Furthermore,we also studied other 1,3-dicarbonyl compounds,which gave one or two molecules Michael addition product.The method provided a new way to synthesize cyclic compounds