头孢噻肟钠与环丙沙星预防生殖内分泌科围手术期感染的最小成本分析

Cost-minimization Analysis of Cefotaxime Sodium vs.Ciprofloxacin for Preventing Infection in Perioperative Period in the Department of Reproductive Endocrinology

目的:评价头孢噻肟钠与环丙沙星预防生殖内分泌科围手术期感染的经济学效果。方法:将2009年7月-2010年1月我院生殖内分泌科符合病例选择标准的患者240例,按随机数字表随机均分为试验组与对照组,按照《抗菌药物临床应用指导原则》规定给药,试验组应用头孢噻肟钠,对照组应用环丙沙星治疗。治疗后观察2组有效性和不良反应,并进行最小成本分析。结果:试验组泌尿道感染1例、呼吸道感染1例、不明原因感染1例,对照组泌尿道感染2例,2组比较差异无统计学意义(P>0.05)。完成治疗分析(PP分析),对照组药物成本、非药物成本、间接成本、总成本分别为(837.75±259.18)、(6145.00±1068.20)、(215.50±60.66)、(7183.10±1182.80)元;试验组分别为(845.97±182.41)、(6183.40±1026.70)、(204.19±56.65)、(7233.60±1108.30)元,2组比较差异均无统计学意义(P>0.05)。结论:头孢噻肟钠与环丙沙星在预防生殖内分泌科围手术期感染的药物经济学方面无显著性差异,但氟喹诺酮类药物耐药率较高,在临床选择使用时需根据实际情况选择合适的抗菌药物。

OBJECTIVE：To evaluate the pharmacoeconomic effectiveness of cefotaxime sodium vs.ciprofloxacin for preventing infection in perioperative period in the department of reproductive endocrinology.METHODS：240 cases of patient from July 2009 to January 2010 who met the selection criterias were selected in the department of reproductive endocrinology in our hospital.They were randomly divided into the treatment group（cefotaxime sodium） and the control group（ciprofloxacin） as 1：1.Patients were administed as Clinical guidelines for antibiotics.The curative effects and adverse events were monitored and the cost-minimization analysis was conducted.RESULTS：In control group,2 cases of urinary tract infection.In the treatment group,1 cases of urinary tract infection,1 case of respiratory tract infection,1 case of infection of unknown causes,and there was no statistical difference between the 2 groups（P0.05）.In control group,the drug cost,non-drug cost,time cost and total coat were（837.75±259.18）,（6 145.00±1 068.20）,（215.50±60.66）,（7 183.10±1 182.80） yuan;In the treatment group,they were（845.97±182.41）,（6 183.40±1 026.70）,（204.19±56.65）,（7 233.60±1 108.30） yuan.There was no statistical difference between 2 groups（P0.05）.CONCLUSION：There was no statistical difference between cefotaxime and ciprofloxacin for preventing infection in perioperative period in the department of reproductive endocrinology about the pharmacoeconoic.Due to the high resistance rates of quinolone,we recommended cefotaxime sodium.