环丙沙星致不良反应46例文献分析

Literature Analysis of 46 Cases of Adverse Drug Reaction Induced by Ciprofloxacin

目的:探讨环丙沙星致不良反应(ADR)发生的规律及特点,为临床合理用药提供参考。方法:通过中国知网数据库(CNKI)检索有关环丙沙星ADR的文献,并进行统计、分析及评价。结果:环丙沙星可引起多种类型ADR,以全身性损害为主(27例,占58.70%),亦可引起心脏骤停等罕见ADR;其ADR发生率男性较女性稍高;静脉滴注和口服给药均可能发生ADR,静脉滴注给药多在用药1～20min内发生,而口服给药多在用药1～6h内发生;ADR预后均较好。结论:环丙沙星可引起多种ADR,临床应用须高度重视其安全性。

OBJECTIVE：To discuss the characteristics and rules of ciprofloxacin-induced adverse drug reactions（ADR）,and to provide reference for rational drug use in the clinic.METHODS：Retrieved from CNKI database,literatures about ciprofloxacin-induced ADR were collected and analyzed statistically.RESULTS：Ciprofloxacin can cause many types of ADR,the main ADR was systemic damage（27 cases,accounting for 58.70%）,it can also cause rare symptom,including cardiac arrest.The male was higher than the female;ADR can be caused by intravenous infusion and oral administration,ADR induced by intravenous administration mostly occurred 1～20 min and oral administration in 1～6 h;ADR prognosis was satisfactory.CONCLUSION：Ciprofloxacin can cause a variety of ADR,so we should pay attention to its clinical applications and safety.