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蛋白酪氨酸磷酸酶SHP-1在细胞信号系统中的负调控作用 被引量：2

Negative effects of protein tyrosine phosphatase SHP-1 in cell signaling
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摘要 Src同源区2蛋白酪氨酸磷酸酶-1（SHP-1）主要表达在造血源性细胞胞质中，是改变胞内磷酸化水平的关键因子。SHP-1在不同的细胞中可产生不尽相同的胞内信号，从而发挥各种功能。 SHP-1 is the protein tyrosine phosphatase which is mainly expressed in the cytoplasm of hematopoietic-derived cells, and it is the key factor to change the levels of intracellular phosphorylation. SHP-1 can generate different intracellular signals in different cells, and it can play various functions.
作者 彭纲 曹如波 伍钢
机构地区 华中科技大学同济医学院附属协和医院肿瘤中心
出处 《国际肿瘤学杂志》 CAS 2012年第7期485-488,共4页 Journal of International Oncology
关键词 蛋白酪氨酸激酶类 信号传导 免疫系统 造血系统 Protein-tyrosine kinases Signal transduction Immune system Hematopoietic system
分类号 R730.2 [医药卫生—肿瘤]
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参考文献20

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同被引文献20

  • 1Oka T, Ouchida M, Koyama M, et al. Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methy- lation in leukemias/lymphomas[J]. Cancer Res, 2002, 62(22) :6390-6394.
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  • 8Cremin Suzanne,Menton John F,Canier Lydie,et al.The prevalence and genotype of human papillomavirus on cervical samples from an Irish female population with external genital warts.Human Vaccines&Immunotherapeutics,2012,8(7):916-920.
  • 9邓列华,李璟蓉,胡云峰,许向前,吴焱,徐瑾,郭秀枝,刘洁,范洪涛,林泽,赵永铿.尖锐湿疣组织中生存素、环氧合酶-2和血管内皮生长因子的表达及其与血管生成的关系[J].中华皮肤科杂志,2010,43(11):766-769. 被引量：7
  • 10李彦希,王苏平.尖锐湿疣的治疗进展[J].中国皮肤性病学杂志,2010,24(12):1157-1158. 被引量：11

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国际肿瘤学杂志
2012年 第7期

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