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肿瘤血管生成机制研究进展 被引量：3

Mechanism of tumor angiogenesis
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摘要 肿瘤的进展和转移必须依赖新生血管的支持，为了达到切断肿瘤血氧供应而抑制甚至治愈肿瘤的目的，研究人员在肿瘤血管生成机制方面进行了大量的研究并取得了一些成果。这些成果表明，众多的因素共同参与了肿瘤的血管新生过程，各种因素通过细胞和分子机制相互作用，构成了肿瘤血管新生的复杂调控网络。 Based on the theory of tumor angiogenesis, the vascular system is necessary for the advance and metastasis of the tumor. To inhibit or even cure the tumor, the researchers all over the world have made a great many of studies on the mechanism of tumor angiogenesis and have acquired some achievements. Based on the findings, a lot of factors are involved in tumor angiogenesis, and they constitute the complex regulating net- work through interaction at the molecular and cellular level.
作者 耿良 花宝金
机构地区 中国中医科学院广安门医院肿瘤科
出处 《国际肿瘤学杂志》 CAS 2012年第7期492-497,共6页 Journal of International Oncology
基金 国家自然科学基金资助项目（30973839）
关键词 肿瘤 血管生成 调控机制 Neoplasms Angiogenesis Regulating mechanism
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献30

  • 1North S, Moenner M, Bikfalvi A. Recent developments in the regula- tion of the angiogenic switch by cellular stress factors in tumors. Can cer Lett, 2005, 218(1):1-14.
  • 2Lee S, Jilani SM, Nikolova GV, et al. Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular pat- terning in tumors. J,Cell Biol, 2005, 169(4) :6814~91.
  • 3Anand S, Majeti BK, Acevedo LM, et al. MicroRNA-132-mediated loss of pl20RasGAP activates the endothelium to facilitate pathological angiogenesis. Nat Med, 2010, 16(8) :909-914.
  • 4Niu G, Chen X. Vascular endothelial growth factor as an anti-angio- genic target for cancer therapy. Curr Drug Targets, 2010, 11 (8): 1000-1017.
  • 5] Yana I, Sagara H, Takaki S, et al. Crosstalk between neovessels and mura ceils directs the site-specific expression of MTI-MMP to endo- thelial tip cells. J Cell Sci, 2007, 120 ( Pt 9) : 1607-1614.
  • 6Weis SM. Evaluating integrin function in models of angiogenesis andvascular permeability. Methods Enzymol, 2007, 426:505-528.
  • 7Del Pozo MA, Schwartz MA. Rac, membrane heterogeneity, caveolin and regulation of growth by integrins. Trends Cell Biol, 2007, 17 (5) :246-250.
  • 8Carnevale E, Fogel E, Aplin AC, et al. Regulation of postangiogenic neovessel survival by betal and beta3 integrins in collagen and ? brin matrices. J Vasc Res,2007,44( 1 ) :40-50.
  • 9Li H, Shi X, Liu J, et al. The soluble fragment of VE-cadherin inhibits angiogenesis by reducing endothelial cell proliferation and tube capillary formation. Cancer Gene Ther, 2010, 17 ( 10 ) : 700- 707.
  • 10Pirotte S, Lamour V, Lambert V, et al. Dentin matrix protein 1 induces membrane expression of VE-cadherin on endothelial ceils and inhibits VEGF-induced angiogenesis by blocking VEGFR-2 phosphorylation. Blood, 2011, 117 ( 8 ) :2515-2526.

二级参考文献22

  • 1Kalluri R.Basement membranes:Structure,assembly and role in tumour angiogenesis[J].Nature Rev Cancer,2003,3:422.
  • 2Tlsty TD,Hein PW.Know thy neighbor:Stromal cells can contribute oncogenic signals[J].Curr Opin Genet Dev,2001,11(1):54.
  • 3Elenbaas B,Weinberg R A.Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation[J].Exp Cell Res,2001,264:169.
  • 4Tomasek J J,Gabbiani G,Hinz B,et al.Myofibroblasts and mechanoregulation of connective tissue remodelling[J].Nature Rev Mol Cell Biol,2002,3:349.
  • 5Parsonage G,et al.A stromal address code defined by fibroblasts[J].Trends Immunol,2005,26:150.
  • 6Bhowmick N A,Neilson E G,Moses H L.Stromal fibro blasts in cancer initiation and progression[J].Nature,2003,432:332.
  • 7Mueller M M,Fusenig N E.Friends or foes-bipolar effects of the turnout stroma in cancer[J].Nature Rev Cancer,2004,4:839.
  • 8Kuperwasser C,et al.Reconstruction of functionally normal and malignant human breast tissues in mice[J].Proc Natl Acad Sci USA,2004,101:4966.
  • 9Bhowmick N A,et al.TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia[J].Science,2004,303:848.
  • 10Barcellos Hoff MH,Ravani SA.Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells[J].Cancer Res,2000,60(5):1254.

共引文献4

同被引文献18

  • 1Jemal A, Bray F, Center MM, et al. Global cancer statistics [J]. CACancer J Clin, 2011,61(2): 69-90.
  • 2Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012 [J]. CACancer J Clin, 2012,62(1): 10-29.
  • 3Feng S, Agoulnik IU, Truong A, et al. Suppression of relaxin recep-tor RXFP1 decreases prostate cancer growth and metastasis [J]. En-docrRelat Cancer, 2010, 17(4): 1021-1033.
  • 4Jager W, Moskalev I, Janssen C, et al. Ultrasound-guided intramuralinoculation of orthotopic bladder cancer xenografts: a novelhigh-precision approach [J]. PLoS One, 2013,8(3): e59536.
  • 5萧云备,张晓威,牛屹东,等.前列腺癌动物模型[J].实验动物学,2010, 27(6): 55-58.
  • 6Naiki T,Asamoto M, Toyoda-Hokaiwado N,et al. Organ specificGst-pi expression of the metastatic androgen independent prostatecancer cells in nude mice [J]. Prostate, 2012, 72(5): 533-541.
  • 7Shen ZY, Shen E, Zhang JZ,et al. Effects of low-frequency ultra-sound and microbubbles on angiogenesis-associated proteins in sub-cutaneous tumors of nude mice [J]. Oncol Rep, 2013, 30(2):842-850.
  • 8Guo CY, Wang XF, Xu KX, et al. Inhibitory effect of doxazosin onthe growth of transplanted tumor of prostate cancer ceil PC-3 innude mice [J]. Beijing Da Xue Xue Bao, 2005,37(3): 273-277.
  • 9Gray DR, Huss WJ, Yau JM, et al. Short-term human prostate prima-ry xenografts: an in vivo model of human prostate cancer vascula-ture and angiogenesis [J]. Cancer Res, 2004, 64(5): 1712-1721.
  • 10Wang Y, Revelo MP, Sudilovsky D, et al. Development and charac-terization of efficient xenograft models for benign and malignant hu-man prostate tissue [J]. Prostate, 2005,64(2): 149-159.

引证文献3

二级引证文献4

国际肿瘤学杂志
2012年 第7期

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