癌性恶病质的诊断和治疗

Cancer cachexia diagnosis and therapy

癌性恶病质传统的治疗方法一般在晚期进行干预，以增加营养摄人为主，并且多以体重做为判断疗效的标准，大量临床试验证明效果并不理想。最近的研究表明在恶病质早期即以蛋白酶体为靶点进行靶向治疗，并与传统治疗相结合，治疗后核因子-κB（NF-κB）水平降低，肌纤维蛋白破坏终止，血浆蛋白及瘦体数量升高，功能好转。

Cancer cachexia （CC） caused by cancer is a syndrome with complicated symptoms. Tradi- tional therapies usually give interventions for more nutrition intake at CC late stage and take weight as the out- come marker. Lots of clinical trials demonstrate that the effect is not satisfactory. Recent studies show that the level of NF-kB decreased, termination of the breakdown of myofibrillar proteins, the serum proteins and lean body mass increased and function improvement after targeting proteasome at early stage of CC combined with tra- ditional therapy.