股骨头缺血性坏死基因治疗及早期影像学监测的研究进展

Advances in gene therapy and early imaging monitoring for avascular necrosis of the femoral head

基因治疗是指将外源性基因导人靶细胞，以纠正或补偿因基因缺陷或异常而引起的疾病，以达到治疗目的。基因治疗作为一种新技术，已用于肿瘤、心血管和神经系统等疾病的治疗，为诸多难治性疾病的治疗带来了曙光。股骨头缺血性坏死是临床难治性疾病，也是骨科常见病，传统的手术疗法和保守疗法都有众多弊端，疗效难以令人满意，而基因治疗作为一种新型疗法，在骨科缺血性疾病的治疗中也展现了光明前景，大量动物实验已经证实了其可行性。该文着重介绍股骨头缺血性坏死基因治疗及早期监测方面的一些研究进展。

Gene therapy is a method that transfers foreign gene to target cells, so as to correct or compensate the disease which is caused by the gene defects and abnormalities. As a new technology, gene therapy has been used in many fields, such as cancer, cardiovascular and nervous system disease, and it brings some hope for patients with difficult and complicated disease. Avascular necrosis of femoral head is a refractory and common disease in clinical, but the traditional surgery therapy and conservative treatment both have many shortcomings, and the effect is unsatisfactory. As a new technology, gene therapy showed bright future in orthopedics ischemic disease, and its potential feasibility has been confirmed by many animal ex- periments, This article focuses on the research progress of gene therapy and early monitoring in the avascular necrosis of the femoral head.