2型糖尿病中医辨证分型与血清视黄醇结合蛋白4、胰岛素抵抗指数的相关性研究

Clinical Study of the Relationship between Syndrome Differentiation and RBP4 and Insulin Resistance Index

目的:初步探讨血清视黄醇结合蛋白4、胰岛素抵抗指数与中医辨证分型的关系。方法:将入组的300例糖尿病患者进行中医辨证分型,分为阴虚热盛型(58例)、气阴两虚型(177例)、血瘀脉络型(35例)和气虚痰浊型(30例)4组,并设健康对照组(30例)。全部病例监测空腹血糖(FPG)、空腹胰岛素(FINS)、计算胰岛素抵抗指数(IR),测定血清视黄醇结合蛋白4(Retinol binding protein,RBP4)。结果:①气虚痰浊型患者RBP4显著高于健康对照组、血瘀脉络型、阴虚热盛型与气阴两虚型;②RBP4与IR之间呈正相关(r=0.312;P<0.01)。结论:血清视黄醇结合蛋白4与气虚痰浊型糖尿病患者关系密切;血清视黄醇结合蛋白4水平与胰岛素抵抗呈正相关,降低血清视黄醇水平可能是改善胰岛素抵抗的一种新方法。

Objective：To explore the relationship between insulin resistance index,RBP4 and syndrome differentiation preliminarily.Methods：300 patients with diabetes mellitus were divided into four groups based on syndrome differentiation：the asthenia heat due to yin deficiency（58 cases）,qi and yin deficiency（177 cases）,blood stasis（35 cases）,qi deficiency with phlegm（30 cases）;normal controling group（30 cases）.All cases were observed fasting plasma glucose（FPG）,fasting plasma insulin（FINS）,retinol binding protein（RBP4）,calculatied insulin resistance index.Results：1.The group of qi deficiency with phlegm was apparently higher than the normal controling group,blood stasis group,asthenia heat due to deficiency yin group,the group of Qi and yin deficiency;2.RBP4 and IR were positively associated（r=0.312;P0.01）.Conclution：There is close relationship between RBP4 and syndrome of qi deficiency with phlegm with diabetes mellitus and RBP4 positively associated with IR,so reducing RBP4 could be a new method of treating insulin resistance index.