摘要
芳香C—N键广泛存在于药物、活性天然产物和农药中,其构建方法是目前合成热点之一.芳香C—H键到芳香C—N键的转化是重要的有机转化类型,这种转化是构成芳胺的一种高效方法.这种直接转化具有原子经济性,可持续发展性以及环境友好的特点.主要以芳香C—H键的氮宾插入和氧化胺化为主线,综述了近十年来该领域的研究进展.
Amines are important compounds that are found throughout the pharmaceutical, bioactive natural products and agrochemical industries. The transformation from aromatic C--H bond to aromatic C--N bond is an important organic con- version. It is an effective method for the construction of aromatic amine. This transformation has the characteristic of atom economy, sustainable development and environment friendly. This review is focused on the research progress in the direct amination of C--H bonds in the past decade.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2012年第7期1208-1216,共9页
Chinese Journal of Organic Chemistry
关键词
芳香C—H键的活化
胺化
芳胺
氮宾插入
氧化胺化
activation of aromatic C--H bond
amination
aromatic amine
nitrene insertion
oxidative amination
