N-(末端三甲基硅苄基甘氨酸肽链)-2,3-萘二甲酰亚胺的光诱导单电子转移成环反应

Photoinduced Single Electron Transfer Cyclization Reaction of N-(Amidosilane terminated polybenzylglycine peptide chain)-2,3-naphthalimide

以苄基甘氨酸为起始物合成了新型分子内给受电子体系N-(末端三甲基硅苄基甘氨酸肽链)-2,3-萘酰亚胺(1).1在MeOH-30%H2O中发生光诱导单电子转移反应,以很高的区域选择性生成新型环苄基甘氨酸肽化合物2.所有新化合物均经MS和NMR确定结构.

Benzylglycine was used as starting material for the synthesis of novel intramolecular electron donor-accepter sys- tem N-（amidosilane terminated polybenzylglycine peptide chain）-2,3-naphthalimide （1）. 1 could undergo a photoinduced sin- gle electron transfer cyclization reaction in MeOH-30% H20 solvent to provide novel cyclopolyglypeptides 2 in high regioselectivity. The structures of all the new compounds were characterized by MS and NMR techniques.