利用Diels-Alder反应构建桉烷类倍半萜骨架关键中间体的研究

Studies on Constructing of the Key Intermediate of Eudesmane Sesquiterpenoid Analogues via Diels-Alder Reaction

以3-甲基-1,3-间苯二酚和异戊醛为原料分别合成亲双烯2-甲氧基-6-甲基对苯醌和双烯1-甲氧基-3-异丙基-1,3-丁二烯,通过Diels-Alder反应,高区域选择性地得到桉烷类倍半萜骨架中间体2c.

The key intermediate of eudesmane sesquiterpenoid analogue 2c was synthesized with high regioselectivity via Diels-Alder reaction from the dienophile 2-methoxyl-6-methyl-l,4-benzoquinone and the diene 1-methoxyl-3-isopropyl-1, 4-butadiene.