磁旋治疗仪对大鼠心、肝、肾等器官部分血清学指标的影响

Effects of magnetic field rotation machine on serological indexes of rats' major organs

目的通过检测心脏、肝脏和肾脏等器官部分血清学指标,探讨ZCX-Ⅱ型磁旋治疗机的生物安全性。方法选用健康成年Wistar大鼠,以表磁5700高斯,最高磁3090高斯,旋转频率12～16 Hz,模拟治疗剂量照射1次/d,1.5 h/次;分别于照射3、6、12 d后采血4～7 ml,检测心、肝、肾等器官部分血清学指标。结果磁旋治疗仪辐照后,大鼠一般自主活动未见异常,但辐照后肛温明显升高,雄鼠有睾丸脱出的现象。血常规、心、肝、肾功能和免疫球蛋白等大部分指标未见明显异常,但A/G显著降低;肌酐水平显著升高。结论 ZCX-Ⅱ型磁旋治疗机治疗剂量辐照对心脏和免疫系统是安全的,对肝脏和肾脏的影响需要进一步论证。

Objective To discuss the biological safety of ZCX - Ⅱ magnetic field rotation machine through detecting the serological indexes of rats ＇ organs such as heart,liver, and kidney, etc. Methods Fifty healthy adult Wistar rats were selected to receive the simulated therapeutic dose of irradiation once per day and for 1.5 h at each time with the outside magnetic strength of 5700 gausses,the maximum magnetic strength of 3090 gausses, and the rotation frequency of 12 - 16 Hz. Blood samples of 4 - 7 ml were obtained respectively 3,6, and 12 d after the irradiation, and the serological indexes of organs such as heart,liver, and kidney, etc, were detected. Results After the irradiation by the magnetic field rotation machine, there were not any abnormal changes in those rats＇ general behavior,but the rectal temperature significantly increased. Prolapse of testicle occurred in male rats. There was no abnormality observed in the most indexes of routine blood test, cardiac, hepatic, renal functions, and immunoglobin. But the ratio of A/G significantly decreased,and the level of Cr significantly increased. Conclusion The therapeutic dose of irradiation by ZCX - Ⅱ magnetic field rotation machine is safe for heart and immune system, but its effects on liver and kidney need further verification.