谷氨酰胺对良性梗阻性黄疸患者术后免疫功能的影响

Clinical study of the role of glutamine in immunological function during postoperative obstructive jaundice

目的探讨谷氨酰胺对梗阻性黄疸免疫功能的影响。方法收集48例良性梗阻性黄疸患者的临床资料,并对患者血清的内毒素(ET)、可溶性白细胞介素2受体(sIL-2R)、T淋巴细胞亚群、免疫球蛋白等进行检验。结果谷氨酰胺干预组和梗阻性黄疸对照组相比,谷氨酰胺干预组血清中的sIL-2R较梗阻性黄疸对照组下降明显;两组T淋巴细胞亚群、免疫球蛋白、ET和sIL-2R水平的变化差异具有统计学意义。结论谷氨酰胺对良性梗阻性黄疸术后的免疫功能变化具有一定的影响。

Objective To investigate the influence of glutamine on immune function in patients with postoperative obstructive jaundice.Methods Clinical data and serum was collected from 48 patients who experienced obstructive jaundice following general surgery.Twenty-four of the patients were assigned to the glutamine intervention group.The levels of endotoxin,soluble interleukin-2 receptor（sIL-2R）,T lymphocyte subgroups,and immunoglobulins were measured and compared between the untreated control and glutamine-treated groups.Results The serum levels of endotoxin and SIL-2R were significantly lower in glutamine-treated patients than in the untreated controls.The levels of T lymphocyte subgroups and immunoglobulins variably increased and decreased during the glutamine treatment period,but were consistently significantly different from the levels in the untreated control group.Conclusion Postoperative treatment with glutamine can modulate levels of immunological factors,and presumably immune function,in patients with obstructive jaundice.