超敏C反应蛋白在脑出血患者中的变化及醒脑静对其的影响

Changes of high sensitivity C-reactive protein in intracerebral hemorrhage patient and the influence of Xingnaojing injection on it

目的观察脑出血患者血清超敏C反应蛋白(hs-CRP)的变化,并探讨醒脑静对其的影响。方法将132例住院的脑出血患者随机分为2组:治疗A组70例予醒脑静注射液及常规治疗,治疗B组62例予常规治疗,均在治疗前及治疗后14 d时空腹采血测定hs-CRP水平;采用美国国立卫生院卒中量表(NIHSS)、日常生活能力评定量表Barthel(BI)对疗效进行评定。另选择年龄、性别比较相似的健康体检者60例作为对照组,均在体检时、体检后14 d时空采血测定hs-CRP。结果治疗A组和治疗B组治疗前hs-CRP均明显高于对照组(P均<0.01);治疗后,治疗A组hs-CRP较治疗B组明显降低(P<0.05),治疗A组疗效较治疗B组明显(P<0.05)。结论脑出血患者血清hs-CRP明显升高,醒脑静可降低脑出血患者血清hs-CRP的含量,改善脑出血患者的预后。

Objective It is to observe the changes of high sensitivity C -resctive protein （hs -CRP） in serum on intrace- rebral hemorrhage patient and to explore the effect of Xingnaojing injection on it. Methods 132 cases of hospitalized patients with intracerebral hemorrhage disease were randomly divided into 2 groups. The 70 patients of the treatment A group were giv- en Xingnaojing injection and conventional therapy, the 62 patients of the treatment B group were given conventional therapy. The levels of hs - CRP at fasting blood in all patients were measured before beginning of treatment, and after 14 days＇treat- ment. The clinical efficacy were evaluated by NIHSS and BI to all patients. At the same time 60 cases of normal healthy indi- viduals with the similar age and gender were collected as control group and their hs - CRP levels in fasting blood were also measured. Results The level of serum hs - CRP of the treatment groups before treatment was increased significantly compared with that in control group （ P 〈 0.01 ）. The level of serum hs - CRP of the treatment A group after treatment was decreased dra- matically compared with that in the treatment B group（ P 〈 0.05 ）. Conclusion The serum hs -CRP in cerebral hemorrhage patients increase obviously, Xingnaojing injection could reduce serum hs - CRP and improve the prognosis of patients with in- tracerebral hemorrhage disease.