肝素预防过敏性紫癜性肾炎的临床效果

目的对肝素预防过敏性紫癜性肾炎(HSPN)的临床效果进行分析。方法随机抽取2008～2011年期间患过敏性紫癜的患者186例,随机分为对照组和观察组各93例。对两组患者均进行基础治疗,观察组患者在此基础上进行肝素钠以及葡萄糖注射液的静脉注射,每天1次,持续进行10d。随访患者尿常规检查结果。结果观察组中的患者出现肾炎的几率明显较小(15例),出现肾炎的时间明显更迟(3.51±0.29个月),并且观察组中的患者没有出现不良反应症状。结论肝素一定程度上能够预防甚至减少HSPN发生的概率,并且能够有效地对患者的肾脏进行保护,有一定的临床意义。

Objective Clinical analysis of the effects of heparin, the purpose of prevention of allergic purpura nephritis （HSPN）. Methods Randomly selected 186 cases of the period 2008 to 2011 in patients suffering from allergic purpura were randomly divided into control group and observation group of 93 cases. The basic treatment, two groups of patients The patients on this basis, the intravenous injection of heparin sodium and glucose injection, once daily, ongoing 10d. Patients were followed up urine test results. Results Observation of the group of patients the risk of nephritis was significantly smaller （15 cases）, the nephritis significantly later （3.51 ± 0.29 months） and observation group in patients with no symptoms of adverse reactions. Conclusion Hepafin to a certain extent, can prevent or even reduce the probability of occurrence by HSPN, and can effectively protect kidney patients, the clinical significance.