肝星形细胞凋亡机制的最新进展

Advances in Studies on Apoptic Factors of Hepatic Stellate Cell

慢性肝病是全球重要死因之一,各种致病因素所致慢性肝损伤均可引起肝纤维化。近年来临床和实验数据均显示肝纤维化甚至肝硬化均可通过肝星形细胞(HSC)的凋亡而得以逆转,因此,阐明肝星形细胞凋亡的分子机制成为发展抗纤维化药物的重要途径之一。肝星形细胞的凋亡受多种因素调控,包括生长因子及其受体、自然杀伤细胞、细胞外基质组分、神经内分泌通路、药物制剂以及翻译后修饰均可影响肝星形细胞的凋亡。在此就各相关因素进行综述。

Chronic liver disease is a major cause of death around the world,Chronic liver injury caused by various kinds of pathogenic factors can lead to liver fibrosis.Emerging experimental and clinical evidence is starting to show that liver fibrosis even early cirrhosis is potentially reversible.Key to this is the discovery that reversion of fibrosis is accompanied by of hepatic stellate cell（HSC）apoptosis.So,Clarifying the mechanism of HSC apoptosis is an important way to develop new antifibrosis medicine.Apoptosis of HSC are regulated by many factors,including cytokines and its receptors,natural kill cells,extracellular matrix,neuroendocrine signaling,pharmacological agents and post-translational modification.Here is to make a review on the related factors.