摘要
克罗恩病是一种贯穿肠道全层的增殖性疾病,有慢性持续性肠道炎症,各种炎性因子、致纤维化因子等分泌增加,肠间质细胞过度增殖、肠壁上细胞外基质沉积及肠道肌层过度生长,肠壁组织结构紊乱并明显增厚,导致肠壁纤维化形成。肠壁纤维化是克罗恩病最严重的并发症之一,目前尚无较好的治疗方法,有待于对其发生机制进一步研究,为临床治疗提供线索。
Crohn′s disease is a chronic and persistent inflammatory bowel disease throughout all the intestinal layers,featured with various inflammatory factors and the fibrosis factors secretion increase,intestinal mesenchymal cells over-proliferation,the extracellular matrix deposits on the bowel wall and intestinal muscle layer excessive growth,intestinal wall structure disorder with the bowel wall obvious thickening,which cause the intestinal fibrosis,which is one of the most serious complications.Currently there is no good therapies,calling for future study on the genesis mechanism to provide clues for the clinical treatment.
出处
《医学综述》
2012年第12期1820-1822,共3页
Medical Recapitulate
关键词
克罗恩病
纤维化
细胞外基质
Crohn′s disease
Fibrosis
Extracellular matrix
