干扰素λ的表达机制

Mechanisms of Interferon-λ Expression

干扰素λ(IFN-λ)是具有抗病毒活性的细胞因子,含有Ⅰ型IFN的生物学功能。IFN-α的表达由多个IFN调节因子(IRFs)顺式原件激活,IFN-β通过上游的增强子区域的协调活动来诱导产生,IFN-λ可通过IFN调节因子(IRFs)和核因子κB(NF-κB)单独诱导。这种调节IFN-λ表达的机制在决定该细胞因子的生物学功能方面起了重要作用。不同类型IFN的表达机制可能存在很大的差异,在此对IFN-λ的表达机制的相关文献予以综述。

Interferon-λ（IFN-λ）are antiviral cytokines with type I IFN-like biological functions.While IFN-α expression is activated by multiple IFN regulatory factors（IRFs）-binding cis-promoter elements,and IFN-β is induced by coordinated action of a multifactor enhanceosome,IFN-λ are induced through independent actions of IRFs and nuclear factor-κB（NF-κB）.The mechanisms governing IFN-λ expression plays an important part in dictating the biological fuction of the cytokine.Here is to make a review on the literature on IFN-λ expression and propose that important differences may exist between the mechanisms governing expression of different IFNs.