线粒体在支气管平滑肌细胞增殖中的调控作用

Regulation Effects of Mitochondria to Bronchoscopy Smooth Muscle Cell Proliferation

慢性阻塞性肺疾病(COPD)是一种常见的慢性疾病,支气管平滑肌细胞(BSMC)增殖是COPD重要的病理特征之一。氧化应激可刺激多种细胞增殖,亦可能刺激支气管平滑肌细胞增殖,进而导致COPD的发生和加重。在氧化应激状态下,线粒体通过调节线粒体融合蛋白2表达调节BSMC的增殖、分化、凋亡。现就线粒体在BSMC增殖中发挥的调控作用进行综述。

Chronic obstructive pulmonary disease（COPD）is a kind of common chronic disease,bronchus smooth muscle cells（BSMC）proliferation is one of the important pathological characteristics.Oxidative stress can stimulate many kinds of cells proliferation,oxidative stress may as well stimulate bronchus smooth muscle cells proliferation,and then induce COPD generation and aggravation.In the state of oxidative stress,mitochondria regulates the proliferation,differentiation,apoptosis of BSMCs through regulate mitofusin2（Mfn2）expression.Here is to make a review on the mitochondria role in the regulation of BSMC proliferation.