摘要
凋亡在B淋巴细胞的发育及肿瘤发生中的作用非常重要。B淋巴细胞肿瘤的发生和化疗耐药机制通常包括Bcl-2蛋白家族失调和p53/p14ARF通路改变。然而Burkitt淋巴瘤细胞株Raji细胞凋亡通路中Apaf-1或DFF-40异常,而非Bcl-2、p53异常诱发凋亡耐受的研究结果令人关注。进一步探索B细胞淋巴瘤凋亡失调的机制,开发新的靶向治疗药物,或将为B细胞淋巴瘤的治疗带来新的希望。
Apoptosis is essential for normal B-lymphocyte development and the tumorigenesis.Dysregulation of the Bcl-2 related proteins and alterations of the p53/p14ARF pathway are implicated in the pathogenesis and treatment resistance in human B-cell malignancies.In the past decade,the studies found that the mechanism of dysregulated apoptosis in Burkitt lymphoma cell line Raji was more related to DFF-40 and Apaf-1,than Bcl-2 or p53 dysfunctions,which drew more and more eyes on these results.Further exploration of B-lymphocyte apoptosis dysfunction mechanism to develop new target drugs might bring new hope to the treatment of the disease.
出处
《医学综述》
2012年第12期1838-1840,共3页
Medical Recapitulate
基金
2010高等学校博士学科点专项科研基金(20103237110005)
关键词
B淋巴细胞肿瘤
细胞凋亡
凋亡信号通路缺陷
B-cell lymphoma
Cell apoptosis
Apoptosis signal transduction pathway defect
