人体癌胚抗原相关细胞黏附分子1的结构与功能

Structure and Function of Human Carcinoembryonic Antigen-related Cellular Adhesion Molecule 1

人癌胚抗原相关细胞黏附分子1(CEACAMl)是广泛表达于中性粒细胞、巨噬细胞、内皮细胞、上皮细胞及淋巴细胞表面的Ⅰ型跨膜糖蛋白,属癌胚抗原家族免疫球蛋白超家族分子,胞膜外区有Ig样结构域,CEACAM1-L型具有两个免疫受体酪氨酸抑制性基序,其生物学功能包括免疫调节、促进血管形成、调节血管重构、参与细胞凋亡调控、促进腺体管腔形成及调控胰岛素的清除,同时CEACAM1也是致病微生物的黏着受体。

Human carcinoembryonic antigen-related cellular adhesion molecule 1（CEACAM1）is a member of the carcinoembryonic antigen family（CEA）which is a type I-transmembrane glycoprotein broadly expressed on the surface of cells including macrophages,neutrophilic granulocyte,lymphocyte,epithelial,and endothelial cells.It is an adhesion molecule of immunoglobulin superfamily.The extracellular domain of CEACAM1 contains IgG-like structure.The long form of CEACAM1 protein has two immunoreceptor tyrosine-based inhibitory motifs（ITIMs）that have crucial roles in immuno-regulation,vascular neogenesis,vascular remolding,cell apoptosis regulation,gland lumen formation and insulin clearance.CEACAM1 is also a receptor for pathogenic bacteria and viruses.