穿梭蛋白核仁素的多种生物学功能

Biological Functions of Shuttling Protein—Nucleolin

核仁素(又称C23)是一段进化保守的核仁-胞质-细胞膜穿梭蛋白,是真核细胞核仁中含量最丰富的蛋白之一;它含有三个结构域,具有多种配体结合活性,在调控细胞分化、增殖、胚胎发生、核糖体合成与成熟、细胞凋亡、病原体侵袭等方面发挥着广泛的生物学功能。在此根据核仁素在细胞内和细胞膜两种物理定位分为两个方面分别介绍其发挥的生物学活性和与其结合的相应配体,揭示特异性干涉其活性的途径。

Nucleolin（also called C23）is a highly-conserved protein which can shuttle between nucleus,cytoplasm and cell membrane,one of the most abundant proteins in nucleus;it can bind to various ligands with its three domains,modulating a wide range of biological functions such as cell differentiation,cell proliferation,embryogenesis,ribosome synthesis and maturity,apoptosis,pathogens invasion and so on.Here,we foucus on its functions and the corresponding ligands inside and outside of the cell,revealing ways of specifically interfering its activities.