257例非霍奇金淋巴瘤患者乙型肝炎病毒感染分析

Analysis of 257 Malignant Lymphoma Patients with HBV Infection

目的探讨恶性淋巴瘤患者中乙型肝炎病毒(HBV)的感染率及其与化疗后肝功能损害发生和严重程度的关系。方法对257例初诊恶性淋巴瘤患者不同性别、年龄、分型中HBV感染进行评价;随机抽取恶性肿瘤257例(肝癌除外)和健康志愿者100例,比较HBV感染与非感染患者在治疗过程中及治疗后肝功能损害的情况。结果非霍奇金淋巴瘤(NHL)患者的HBV感染率远高于其他肿瘤患者及正常健康人群;而其他肿瘤患者与健康人群之间无明显差异(P<0.05)。B细胞NHL的HBV感染率均明显高于健康人群;T细胞NHL与健康人群无明显差异,B细胞性NHL患者的HBV感染率明显高于T细胞性NHL,HBsAg阳性者和HBcAb阳性者化疗后肝功能损伤发生率明显高于HBsAg阴性组(P<0.05)。结论化疗后肝功能损伤比较,HBsAg及HB-cAb阳性者化疗后肝功能损伤发生率明显高于阴性者,HBsAg阳性者应提前给予抗HBV病毒治疗,可减轻化疗后肝功能损害;HBcAb与NHL最为密切。

Objective To study the hepatitis B virus（HBV）infection status of diagnosed malignant lymphoma patients,and its correlation with the liver damage incidence and severity of those patients after chemotherapy.Methods HBV infection status of 257 malignant lymphoma patients were analyzed by gender,age,and type.257 cases of malignant tumors（except liver cancer）and 100 healthy volunteers were randomly chosen for comparison;liver damage of HBV infected and uninfected patients during and after the treatment were compared.Results The HBV infection rate of non-hodgkin’s lymphoma（NHL）patients was far higher than other patients with tumor and normal healthy population;there was no obvious difference between other cancer patients and healthy population.HBV infection rate of B cell NHL was significantly higher than the healthy crowd;no obvious difference betweenT cell NHL and healthy population,B cell NHL HBV infection rate was higher than T cell NHL.Liver dysfunction frequently occurred in cases of those HBcAb positive and HBsAg positive patients after chemotherapy（P〈0.05）.Conclusion After chemotherapy,the liver damage rate of HbcAb positive and HbsAg positive was higher than the negative,HBsAg positive group should be given HBV virus treatment in advanceto reduce the chemotherapy damage;HbcAb is the mostly closely correlated with NHL.