不同模式低氧及递增负荷训练对心肌肌球蛋白重链表达的影响

The Effect of Different Models of Hypoxic and Incremental Training on Cardiac Myosin Heavy Chain Expression

目的:主要通过间歇低氧训练和高住低练两种低氧训练模式观察运动即刻状态下大鼠心肌肌球蛋白重链比例表达。方法:48只大鼠分为6组,四周递增负荷跑台实验后,测得心肌肌球蛋白重链及相关指标。结果:①高住低练组较间歇低氧运动组,左心室心肌运动性肥大较为明显(P<0.05);②运动组心肌肌球蛋白β-MHC向α-MHC转化率高于常氧对照组,高住低练组高于间歇低氧运动组,且存在显著性差异(P<0.05);结论:本次实验中就心肌肌球蛋白重链等相关指标而言,高住低练组是本实验设计六组中最为理想的训练模式。

Objective： In this comparative research by Intermittent Hypoxia Training and Hilo Training on Cardiac Myo- sin heavy chain in order to obtain the difference and relationship between the two training models after training; Method： Divided 48 rats into six groups, after 4 weeks incremental exercise , measured cardiac myosin heavy chain and related indexes; Results：（1） Hilo Training compared to Intermittent Hypoxia training group, exercise-induced left ventricular hypertrophy is more evident （P〈0. 05） ; （2）Exercise group cardiac myosin β-MHC to α-MHC conversion rate is higher than normal group, Hilo Training is higher than Intermittent Hypoxia Training group, and there was significant difference （P〈0. 05） ; Conclusion：For this experiment cardiac myosin heavy chain and other related indicators, Hilo Training group is the most ideal training model of six design groups.