紫癜性肾炎患者血浆TM、vWF和IL-8水平的变化

The changes of plasma thrombomodulin,von Willebrand factor and interleukin 8 in children with purpura nephritis

目的探讨紫癜性肾炎患儿血浆血栓调节蛋白(TM)、血管性假性血友病因子(vWF)和白细胞介素8(IL-8)水平的变化及其与紫癜性肾炎临床分型的相关性。方法选择过敏性紫癜患儿65例(HSP组);其中过敏性紫癜性肾炎(HSPN)51例,无肾损害者14例(HSP单纯型)。51例HSPN患儿分为:孤立性血尿或孤立性蛋白尿18例(HSPN 1型),血尿和蛋白尿14例(HSPN 2型),急性肾炎型11例(HSPN 3型),肾病综合征型8例(HSPN 4型)。对照组为我科门诊体检的健康儿童19例。分别测定血浆TM、vWF、IL-8水平,分析血浆TM、vWF、IL-8与紫癜性肾炎临床分型的关系。结果 HSP组血浆TM、vWF、IL-8高于对照组(P<0.05),HSPN 2、3、4型患儿血浆TM、vWF、IL-8明显高于单纯型(P<0.05)。结论紫癜性肾炎患儿血浆TM、vWF、IL-8水平随着临床分型不同而变化。联合测定有助于紫癜性肾炎的早期诊断和治疗。

Objective To investigate the relationship between the changes of plasma thrombomodulin（TM）, yon Willebrand factor （vWF）, interleukin 8 （ IL-8 ） and clinical classification of purpura nephritis. Methods Plasma TM,vWF and IL-8 were measured in 65 children with Henoch- Schonlein purpura（group HSP） and 19 healthy children（group C）. The patients in group HSP included 51 cases with allergy purpuric nephritis（HSPN） and 14 cases with allergic purpura without nephropathy. HSPN patients were divided into 4 types of HSPN-1 （18 cases, isolated hernaturia or proteinuria）, HSPN-2 （ 14 cases, hematuria and proteinuria）, HSPN-3 （ 11 cases, acute nephritis） ; and HSPN-4 （8 cases, nephrotic syndrome）. The relationship between the changes of plasma TM, vWF and IL-8 and clinical classifications of purpura nephritis was analyzed. Results Plasma levels of TM, vWF and IL-8 were higher in group HSP than those in group C（P〈0.05） ,which were higher in the cases with HSPN-2, HSPN-3 and HSPN-4 than those in the cases with allergic purpura without nephropathy（P〈0. 05）. Conclusion Plasma levels of TM, vWF and IL-8 are changed as the clinical classifications of purpura nephritis changed. Combined detection of plasma levels of TM, vWF and II7 8 is helpful in early diagnosis and treatment of purpura nephritis.