对羟基苯乙酸铜(Ⅱ)、锌(Ⅱ)配位聚合物的合成、晶体结构及与DNA作用

Synthesis,Crystal Structures and DNA-Binding of Cu(Ⅱ),Zn(Ⅱ) Coordination Polymer Constructed from 4-Hydroxyphenylacetic Acid

合成了两种过渡金属配合物[M(HPAA)(phen)2]HPAA.7H2O(M=Zn,1;Cu,2;HPAA-=对羟基苯乙酸根;phen=1,10-邻菲啰啉),并通过元素分析、红外光谱、热重分析对其进行表征,用单晶X-射线衍射方法测定了配合物的晶体结构。结构分析显示,两种配合物属于异质同晶型,不对称单元都是由1个金属离子,2个对羟基苯乙酸根离子,2个邻菲啰啉分子和7个游离的水分子组成的,其中有1个对羟基苯乙酸根离子未参与配位。每个金属离子的配位数为6,处于扭曲的八面体配位环境中。另外,用荧光光谱法研究了两种配合物与DNA之间的相互作用。

Two transition metal complexes [M（HPAA）（phen）2]HPAA·7H2O（M=Zn,1;Cu,2;HPAA-=4-hydroxy-phenylacetic acid anion;phen=1,10-phenanthroline） were sythesized and characterized by elemental analysis,IR and TG-DTG.Their crystal structures were determined by single crystal X-ray diffraction method.The crystal structure anlysis reveals two complexes belong to isomorphism,and the asymmetric unit contains one metal ion,two 4-hydroxyphenylacetic acid anions and seven free water molecules,one of acid anions is not coordinated with the metal ion.The metal ion is six-coordinated and involved in a distorted octahedral coordination geometry.In addition,the interaction of complexes with DNA were also studied by ethidium bromide（EB） fluorescence spectroscopy.CCDC： 729804,1;729805,2.