Electrical bioimpedance gastric motility measurement based on an electrical-mechanical composite mechanism

AIM:To introduce a bioimpedance gastric motility measurement method based on an electrical-mechanical composite concept and a preliminary clinical application.METHODS:A noninvasive gastric motility measurement method combining electrogastrogram(EGG) and impedance gastric motility(IGM) test was used.Preliminary clinical application studies of patients with functional dyspepsia(FD) and gastritis,as well as healthy controls,were carried out.Twenty-eight FD patients(mean age 40.9 ± 9.7 years) and 40 healthy volunteers(mean age 30.9 ± 7.9 years) were involved.IGM spectrum was measured for both the healthy subjects and FD patients,and outcomes were compared in the FD patients before treatment and 1 wk and 3 wk after treatment.IGM parameters were obtained from 30 erosive gastritis patients(mean age 50.5 ± 13.0 years) and 40 healthy adults,and IGM and EGG results were compared in the gastritis patients before treatment and 1 wk after treatment.RESULTS:There were significant differences in the IGM parameters between the FD patients and healthy subjects,and FD patients had a poorer gastric motility [percentage of normal frequency(PNF) 70.8 ± 25.5 in healthy subjects and 28.3 ± 16.9 in FD patients,P < 0.01].After 1 wk administration of domperidone 10 mg,tid,the gastric motility of FD patients was not improved,although the EGG of the patients had returned to normal.After 3 wk of treatment,the IGM rhythm of the FD patients became normal.There was a significant difference in IGM parameters between the two groups(PNF 70.4 ± 25.5 for healthy subjects and 36.1 ± 21.8 for gastritis patients,P < 0.05).The EGG rhythm of the gastritis patients returned to normal(frequency instability coefficient 2.22 ± 0.43 before treatment and 1.77 ± 0.19 one wk after treatment,P < 0.05) after 1 wk of treatment with sodium rabeprazole tablets,10 mg,qd,po,qm,while some IGM parameters showed a tendency toward improvement but had not reached statistical significance.CONCLUSION:The electrical-mechanical composite measurement method showed an attractive clinical application prospect in gastric motility research and evaluation.

AIM： To introduce a bioimpedance gastric motility mea- surement method based on an electrical-mechanical composite concept and a preliminary clinical application. METHODS： A noninvasive gastric motility measure- ment method combining electrogastrograrn （EGG） and impedance gastric motility （IGM） test was used. Prelim- inary clinical application studies of patients with func- tional dyspepsia （FD） and gastritis, as well as healthy controls, were carried out. Twenty-eight FD patients （mean age 40.9±9.7 years） and 40 healthy volun- teers （mean age 30.9±7.9 years） were involved. IGM spectrum was measured for both the healthy subjects and FD patients, and outcomes were compared in the FD patients before treatment and 1 wk and 3 wk after treatment. IGM parameters were obtained from 30 erosive gastritis patients （mean age 50.5±13.0 years） and 40 healthy adults, and IGM and EGG results were compared in the gastritis patients before treatment and 1 wk after treatment.RESULTS： There were significant differences in the IGM parameters between the FD patients and healthy subjects, and FD patients had a poorer gastric motility [percentage of normal frequency （PNF） 70.8±25.5 in healthy subjects and 28.3 =t= 16.9 in FD patients, P 〈 0.01]. After 1 wk administration of domperidone 10 mg, tid, the gastric motility of FD patients was not im- proved, although the EGG of the patients had returned to normal. After 3 wk of treatment, the IGM rhythm of the FD patients became normal. There was a significant difference in IGM parameters between the two groups （PNF 70.4：1：25.5 for healthy subjects and 36.1 4- 21.8 for gastritis patients, P 〈 0.05）. The EGG rhythm of the gastritis patients returned to normal （frequency insta- bility coefficient 2.22±0.43 before treatment and 1.77 ：t： 0.19 one wk after treatment, P 〈 0.05） after 1 wk of treatment with sodium rabeprazole tablets, 10 mg, qd, po, qm, while some IGM parameters showed a tenden- cy toward improvement but had not reached statistical significance. CONCLUSION： The electrical-mechanical composite measurement method showed an attractive clinical appli- cation prospect in gastric motility research and evaluation.