期刊文献+

动脉期灌注率预测肝癌肝动脉插管化疗栓塞的疗效

Arterial phase perfusion ratio for assessment of efficacy of transcatheter arterial patients with hepatocellular carcinoma
原文传递
导出
摘要 目的采用超声造影灌注参数预测肝癌肝动脉插管化疗栓塞(TACE)的疗效。方法本院2008年1月至2010年12月的肿瘤直径≥5cm单发肿瘤初诊肝癌69例,首次治疗为TACE。比较患者TACE术前、后肿瘤大小,按RECIST标准进行分组,部分缓解组(PR)21例,疾病稳定组(SD)17例,疾病进展组(PD)31例。采用SonoLiver软件分析肿瘤超声造影灌注曲线的曲线下面积(AUC)、平均渡越时间(mTT)、灌注指数(PI)、达峰时间(TTP)及峰值强度(IMX),采用Image Pro Plus软件分析肿瘤动脉期肿瘤灌注百分率。结果AUC、mTT、PI、TTP及IMX在3组间差异无统计学意义(P〉0.05)。PR组或SD组动脉期肿瘤灌注百分率比PD组大[(78.88±12.19)%,(72.93±15.68)%比(38.97±11.01)%,P〈0.05]。以动脉期肿瘤灌注百分率小于50%为预测指标,筛选PD组病例,诊断符合率为88.4%(61/69),敏感性83.9%(26/31),特异性92.1%(35/38)。结论动脉期肿瘤灌注百分率有可能作为一个新的超声造影参数预测肝癌TACE的疗效。 Objective To predict the efficacy of transcatheter arterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC) by using ultrasonographic perfusion parameters. Methods Sixty-nine patients with primary diagnosis of HCC as having single tumor diameter of i〉5 cm and TACE as initial treatment were enrolled from Sun Yat- sen University Cancer Center between January 2008 and December 2010. Patients were divided into partial response group (PR, n=21 ), stable disease group (SD, n= 17) and progressive disease group(PD, n=31), respectively, based on the RECIST standard and comparison of pre- and post-operative tumor size. Parameters of tumor ultrasonographic perfusion curve, including area under curve (AUC), mean transit time (mTT), perfusion index (PI), time to peak (TTP) and maximum intensity (IMX) , were analyzed by using SonoLiver software, and the arterial phase perfusion ratio was computed via Image Pro Plus software. Results The differences in AUC, mTT, PI, TTP and IMX did not reach statistical significance among groups (all P〉0.05). Group PR and SD yielded higher perfusion ratio in arterial phase than group PD [ (78.88±12.19)%, (72.93±15.68)% vs (38.97±11.01)%, P〈0.05]. Arterial phase perfusion ratio 〈50% as a predictor of patients with PD was associated with a diagnostic accuracy of 88.4% (61/69), sensitivity of 83.9% (26/31) and specificity of 92.1% (35/38). Conclusion Perfusion ratio in arterial phase may be a novel uhrasonographic perfusion parameter for the prediction of efficacy of TACE treatments in patients with HCC.
出处 《中华生物医学工程杂志》 CAS 2012年第3期240-244,共5页 Chinese Journal of Biomedical Engineering
基金 广东省医学科学技术研究基金(B2010110)
关键词 血管造影术 数字减影 肝肿瘤 栓塞 治疗性 疗效 Angiography, digital subtraction Liver neoplame Embolization, therapeutic Efficacy
  • 相关文献

参考文献6

二级参考文献26

  • 1李功杰,杨立,史晓林,李晓兵,郑晓玲,王悦华.原发性肝癌肿瘤微血管形态特征研究[J].解放军医学杂志,2004,29(7):605-606. 被引量:10
  • 2Bosch FX, Ribes J, Diaz M, et al. Primary liver cancer: worldwide incidence and trends[J]. Gastroenterology, 2004, 127 (Suppl 1): s5-16.
  • 3Williams R J. Biochemical individuality the Basis for the Genetotrophic Concept[M]. New York: John Wiley & Sons, Inc ,1956:195.
  • 4Shimozawa N, Hanazaki K. Longterm prognosis after hepatic resection for small hepatocellular carcinoma[J]. J Am Coil Surg, 2004, 198(3):356-365.
  • 5Zhou XD, Tang ZY, Ma ZC, et ai. Surgery for large primary liver cancer more than 10 cm in diameter[J]. J Cancer Res Clin Oncol, 2003, 129(9):543-548.
  • 6Llovet JM, Fuster J, Bruix J. Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: Resection versus transplantation[J]. Hepatology, 1999, 30(6): 1434-1440.
  • 7Figueras J, Ibanez L, Ramos E, et al. Selection criteria for liver transplantation in early stage hepatocellular carcinoma with cirrhosis: results of a multicenter study[J]. Liver Transpl, 2001, 7(10):877-883.
  • 8Lau WY, Leung TW, Yu SC, et al. Percutaneous local ablative therapy for hepatocellular carcinoma: a review and look into the future[J]. Ann Surg, 2003, 237(2):171-179.
  • 9Josep M, Llovet, Sergio Ricci, et al. Sorafenib in Advanced Hepatocellular Carcinoma[J]. N ENGL J med, 2008:359(4):378-390.
  • 10Maeda K, Kang SM, Onoda N, et al. Expression of p53 and vascular endothelial growth factor associated with tumor angiogenesis and prognosis in gastric cancer. Oncology,1998,55:594-599.

共引文献179

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部