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嗅素结构域基因家族在眼科领域的研究进展

Research advances of olfactomedin-domain gene family in ophthalmology
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摘要 嗅素结构域家族是近几年研究比较多的基因家族,因该家族成员蛋白含有嗅素结构域而得名。越来越多的证据表明该家族在神经起源、细胞黏附、细胞周期调节和肿瘤发生发展中发挥有重要作用,而且很可能是许多重要的信号通路(如Wnt信号通路)的调节者,与眼组织正常发育和病理过程有关。本文就近几年来关于该家族成员在眼科的研究进展作一综述。 Olfactomedin-domain family has been the focus of many recent studies.Although there is little knowledge of its biological functions,more and more evidence show the family members play important roles in the neuro-origin,cell adhesion,modulation of cell cycle and tumor genesis and development.It may also be related with many important signal paths such as Wnt signal path,and so may be associated with eye developments and pathological processes.This article reviews the research advances of this family in ophthalmology these years.
作者 孟博 李彬
出处 《眼科新进展》 CAS 北大核心 2012年第8期798-800,共3页 Recent Advances in Ophthalmology
关键词 嗅素结构域家族 OLFM1 OLFM2 Optimedin PAX6 olfactomedin-domain gene family OLFM1 OLFM2 Optimedin PAX6
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