MACC1和c-met在非小细胞肺癌中的表达及其预后价值

Prognostic Value of MACC1 and c-met Expressions in Non-small Cell Lung Cancer

背景与目的已有的研究表明结肠癌转移相关基因1(metastasis-associated in colon cancer1,MACC1)是一个与肿瘤浸润转移相关的新基因,该基因能够调节肝细胞生长因子受体(hepatocyte growth factor receptor,c-met)的表达。本研究旨在探讨MACC1和c-met在非小细胞肺癌(non-small cell lung cancer,NSCLC)组织中的表达及其与浸润转移和预后的关系。方法采用免疫组化检测103例NSCLC组织及40例癌旁正常组织中MACC1和c-met蛋白的表达。结果 MACC1和c-met在NSCLC组中的阳性表达率均明显高于正常肺组织(P<0.001)。MACC1和c-met阳性率均与肺癌的分化程度、T分期、淋巴结转移和TNM分期相关(P<0.05),而与性别、年龄、吸烟及组织学类型等无关(P>0.05)。MACC1和c-met的表达呈正相关(r=0.403,P<0.001)。Kaplan-Meier生存曲线显示MACC1和c-met阳性组5年生存率均明显低于阴性组(P<0.05)。Cox多因素分析显示MACC1是NSCLC的独立预后因素(P=0.026)。结论 MACC1和c-met的表达与肺癌的分化、浸润和转移密切相关,两者均对生存期有一定的影响,MACC1是NSCLC的独立预后危险因素。

Background and objective It has been proven that metastasis-associated in colon cancer 1 （MACC1） is a new gene that is related to the invasion and metastasis of tumors. MACC1 also regulates c-met expression. The aim of this study is to explore the expressions of MACC 1 and hepatocyte growth factor receptor （c-met）, and its relationship with invasion, metastasis, and prognosis of non-small cell lung cancer （NSCLC）. Methods MACC1 and c-met expressions were detected in 103 cases of NSCLC and 40 cases of neighboring normal lung cancer tissue using immunohistochemistry. Results MACC 1 and c-met expressions were significantly higher in lung cancer tissues than that in neighboring normal tissue （P〈0.001）. MACC1 and c-met expressions were associated with poor differentiation, advanced T stages, lymph node metastasis, and advanced TNM stages （P〈0.05） of NSCLC, but not with sex, age, smoking, and histological classification （P〉0.05）. In addition, a positive correlation between MACC1 and c-met expressions was observed （r=0.403, P〈0.001）. ＂Ihe result from the Kaplan- Meier survival analysis showed that the five-year survival rate in patients with positive MACC1 and c-met expressions was remarkanly lower than that in patients with negative expressions （P〈0.05）. The result from the Cox regression analysis showed that MACC1 expression was an independent prognostic factor for NSCLC （P=0.026）. Conclusion MACCI and c-met have an important function in the differentiation, invasion, and metastasis ofNSCLC. MACC1 and c-met have poor prognosis in patients with NSCLC. Moreover, MACC1 expression is an independent prognostic factor for NSCLC.