肺癌脊椎骨转移^(18)F-FDG PET/CT与MRI的对比分析

Evaluation of ^(18)F-FDG PET/CT and MR imaging in the detection of spinal metastasis of lung cancer

目的:比较分析18 F-FDG PET/CT与MRI在肺癌脊椎骨转移诊断方面的敏感性、特异性。方法:28例肺癌PET/CT疑脊椎转移患者行MRI检查,比较两种方法对脊椎转移的显示征象。统计学方法采用配对四格表资料2检验,P<0.05被认为差异有显著性。结果:经病理或随访确诊脊椎骨转移22例。以受累椎体病灶个数为统计单位,脊椎范围内共700个椎体,153个为真阳性,574个为真阴性。PET/CT诊断正确143个病灶,假阴性10个,假阳性24个,其敏感性93.4%,特异性95.6%。MRI诊断正确145个病灶,假阴性8个,无假阳性,其敏感性94.7%,特异性100%。结论:在显示脊椎骨转移方面,MRI较PET/CT具有更高的敏感性、特异性。

Objective： To evaluate the ability of 18 F-FDG PET/CT and MRI in the detection of centrum metastasis of lung cancer and to compare their sensitivity, specificity. Methods： 28 patients with lung cancer were imaged with SF-FDG PET/CT and MRI. All the cases were proved by histopathology. The author compared the demonstration of spinal metas- tases with the two imaging modalities. Statistical analysis was performed using the 2 X 2 contingency table X2 test. A P value of less than 0.05 was considered to indicate statistical significance. Results： In the spinal region, 22 of 28 patients with lung cancer were proved to have spinal metastases. Taking the total lesions as the samples, 153 lesions in 700 spinal were demonstrated as metastatic lesions. In la F-FDG PET/CT, true positive lesions were 143, false negative lesions were 10, false positive lesions were 24, the diagnostic sensitivity was 93.4%, the diagnostic specificity was 95.6%. In MR imaging, true positive lesions were 145, false negative lesions＇were 8, false positive lesions were 0, the diagnostic sensitivity was 94.7%, the diagnostic specificity was 0. Conclusion In diagnosing centrum metastases, MRI is more sensitive and correct than 18 F-FDG PET/CT.