涎腺膜性基底细胞腺瘤的组织发生学研究

Histogenesis and development of membranous basal cell adenoma of the salivary gland

目的 探讨涎腺膜性基底细胞腺瘤的组织发生和发展过程。方法 对 12例涎腺膜性基底细胞腺瘤患者进行组织病理学和免疫组织化学研究。结果 4例患者均可见肿瘤周围的腺体组织中有多灶性纹管增殖 ,其最早期的改变为纹管基底细胞增殖 ,持续不断的导管增殖导致了微小腺瘤的形成。结论 纹管基底细胞的增殖明显参与涎腺膜性基底细胞腺瘤的形成 ,并在其中起主要作用。

Objective To investigate the histogenesis and development of membranous basal cell adenoma in the salivary glands Methods A histological and immunohistochemical study was carried out on 12 cases of membranous basal cell adenoma in the salivary glands Results In 4 cases, multiple focal proliferations of striated ducts in the surrounding salivary gland were conspicuous, which allowed tracing the development of the tumors from their origin The earliest changes were characterized by hyperplasia of the basal cells of striated ducts Continuous ductal proliferation lead to the formation of microadenomas Conclusions Proliferation of basal cells of the striated ducts apparently participate in, and play a main role in the histogenesis of some membranous basal cell adenomas of the salivary glands