雌激素治疗骨质疏松大鼠正畸牙移动的实验

Effects of estrogen on experimental tooth movement in osteoporosis rats

目的 探讨雌激素对骨质疏松患者正畸牙齿移动的影响及其对牙槽骨的作用。方法选用 30只雌性SD大鼠随机分为 3组 ,健康对照组、骨质疏松组、骨质疏松雌激素治疗组。测量 3组不同时期牙齿移动的距离、破骨细胞计数并进行组织学观察。结果 治疗 1个月后 ,骨质疏松组较健康对照组正畸牙齿移动增加 43 3% ,雌激素治疗组增加 30 7% ;破骨细胞计数骨质疏松组较健康对照组增加 6 4 4% ,雌激素治疗组增加 32 9%。治疗 2个月后 ,骨质疏松组移动增加 6 8 5 % ,雌激素治疗组增加 2 4 9% ;破骨细胞计数骨质疏松组增加 6 8 7% ,雌激素治疗组增加 15 0 %。雌激素促进骨矿化增加 ,抑制骨破坏 ,恢复骨再建过程平衡。

Objective To investigate the effects of estrogen on the orthodontic tooth movement and alveolar bone in osteoporosis rats. Methods Thirty 3 month old female sprague dawley rats were divided randomly into three groups (control, osteoporosis and estrogen). In the three groups, the distances of tooth movement and the number of osteoclast were measured and compared. Histologic changes were observed. Results Compared with the control group, in first month, the distances of orthodontic tooth movement was increased by 43.3% in osteoporosis group and by 30.7% in estrogen group; the number of osteoclast was increased by 64.4% and by 32.9% respectively. In second month, the distances were increased by 68.5% in osteoporosis group and by 24.9% in estrogen group; the number of osteoclast was increased by 68.7% and by 15.0% respectively. In addition, estrogen promoted the alveolar bone forming and inhibited the bone resorption. Conclusion It is suggested that the estrogen may affect the rate of orthodontic tooth movement on postmenopausal osteoporosis patient.