肝再生磷酸酶-3及其抑制剂在肿瘤中的作用

Roles of the liver regeneration phosphatase-3 and its inhibitors in tumor

肝再生磷酸酶-3（PRL-3）是新的小分子蛋白质酪氨酸磷酸酶，在肿瘤的发生发展中有重要作用。研究发现，PRL-3通过参与多种信号通路调控肿瘤进展。PRL-3在肿瘤组织中高表达能明显促进肿瘤转移，但在多数正常组织中不表达，因此有望成为肿瘤诊断的标志物及肿瘤治疗的新靶点。

Phosphatase of regenerating liver-3 （PRL-3） is a novel small molecule protein-tyrosine- phosphatase, which plays an important role in the oncogenesis and deveopment of tumors. Studies show that PRL-3 regulates neoplasm progress through participating in multiple signal pathways. Its high expression can significantly promote neoplasm metastasis in cancer tissue. However, there is no expression of PRL-3 in most normal tissue. PRL-3 is expected to be a potential tumor maker of diagnosis and a new target for the therapy of eancer.