他汀类药物辅助治疗颈动脉狭窄的临床观察

The Clinical Observation of Statins on Adjuvant Treatment of Carotid Artery Stenosis

目的探讨他汀类药物辅助治疗颈动脉狭窄的临床疗效。方法将颈动脉狭窄患者800例随机分为对照组400例和治疗组400例,对照组采用常规药物与支架成形术治疗,治疗组在对照组的基础上口服辛伐他汀治疗。结果两组治疗前IMT和斑块面积对比差异无统计学意义,经过治疗后都有显著下降,但是治疗组的下降幅度更大(P<0.05)。治疗组的总胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白(LDL)的下降幅度都比对照组大(P<0.05)。对照组在随访期的病死率明显高于治疗组(P<0.05)。结论他汀类药物应用于颈动脉狭窄患者治疗中能有效减少狭窄程度,减少病死率,其作用的发挥可能与降脂作用有关。

Objective To investigate the clinical efficacy of statin on adjuvant treatment of carotid artery stenosis. Methods 800 cases of carotid artery stenosis were divided into the treatment group of 400 cases and the control group of 400 cases,all cases were used conventional drugs and stent plasty,and the treatment group were added the simvastatin for treating. Results IMT and plaque area in the two groups were decreased significantly after treatment, but the decline of the treatment group were better than the control group（P〈0.05 ）. And the TC, TG and LDL of the treatment group were more decline than the control group （P 〈 0. 05 ）. In the follow-up period, the mortality of the treatment group were higher than the treatment group（P〈0.05 ）. Conclusions The statins used in the treatment of carotid artery stenosis can effectively reduce the degree of stenosis and mortality,its role in the play may be related to the lipid-lowering effects.