哮喘患者血清高敏C-反应蛋白与哮喘控制测试评分相关性研究

Relation between serum high-sensitivity C-reactive protein level and Asthma Control Test score between the correlation research Patients with asthma

目的探讨血清高敏C-反应蛋白(hs-CRP)水平与哮喘控制测试(ACT)评分的关系。方法 45例诊断明确的哮喘患者(轻度19例,中度26例)和45例健康患者纳入研究。分别对研究对象采集病史、体检,依据GINA指南评估哮喘,并行呼吸功能测试(RFT)、ACT评分和血清hs-CRP水平测量。依据ACT评分将哮喘患者分为两组。结果哮喘患者组的hs-CRP水平显著高于对照组的水平(P=0.003)。中度哮喘患者的血清hs-CRP水平明显高于轻度哮喘者的水平(P=0.03)。ACT<20组的hs-CRP水平显著高于ACT≥20组的水平(P=0.01)。hs-CRP水平与ACT评分(R=-0.81,P<0.001)和哮喘的严重程度(R=0.32,P<0.05)呈现显著的相关性。结论 hs-CRP水平与哮喘的严重程度和ACT评分相关,hs-CRP可以作为一个反映哮喘的严重程度和哮喘控制的敏感指标。

Objective To investigate the relationship between the serum level of the high-sensitivity C- reactive protein（hs-CRP） and the asthma control test{ACT） score. Methods Forty-five patients with asthma and 45 healthy controls were included in the study. Medical history was recorded, and physical examination and asthma assessment were performed. The respiratory function tests （ RFT）, the ACT score and serum hs-CRP levels were measured. According to the ACT score,Asthmatic patients were divided into two groups. Results The levels of hs- CRP were significantly higher in asthmatics than those in controls（P = 0. 003）. Serum hs-CRP levels in moderate asthmatics were significantly higher than the level of hs-CRP in mild asthmatics{P= 0.03 ）. The levels of hs-CRP were significantly higher in ACT score 〈20 group than those in ACT score ≥20 group（P=0.01 ）. The correlation between the levels of hs-CRP and ACT score （ R =-0.81, P〈0.001 ） and the severity of asthma （ R = 0.32, P〈0.05 ） were significant. Conclusion The serum level of hs-CRP correlates with the severity of asthma and ACT score,hs- CRP can be used as a sensitive index to reflect the severity of asthma and asthma control.