摘要
目的 探讨白血病抑制因子 (LIF)mRNA及其蛋白在人类早孕蜕膜组织中的表达及定位。方法 采用原位杂交及免疫组织化学方法对 16例正常早孕妇女蜕膜组织中的LIFmRNA及其蛋白的表达进行研究。结果 全部早孕蜕膜组织标本中腺体及间质均有LIFmRNA及其蛋白表达 ,腺体中LIF基因表达高于基质。结论 人类蜕膜组织中LIF表达可能与胚泡着床、维持胎盘功能和促进胚胎发育有关。
Objective To study the expression and localization of leukemia inhibitory factor (LIF) in human first trimester decidual. Method By immunohistochemical analysis and in situ hybridization, the LIF mRNA and protein expressions were observed in 16 cases of human decidua. Results LIF mRNA and protein expressions were observed in all decidual specimens, the glanduar epithelium showed higher LIF expression than in stromal cells. Conclusion Expression of LIF in human decidua may contribute to embryo implantation, maintenance of placental functions and embryonic growth promation.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2000年第4期214-215,I005,共3页
Chinese Journal of Obstetrics and Gynecology
