2010-2012年肾上腺疾病研究进展

The advances of research on adrenal diseases from 2010 to 2012

本文回顾了2010～2012年国内外在肾上腺疾病的基础和临床研究方面的主要进展，内容包括类固醇合成因子1在肾上腺肿瘤中的诊断价值、肾上腺醛固酮分泌腺瘤的发病机制及新的诊断方法、ACTH依赖性重症库欣综合征的治疗、肾上腺意外瘤伴亚临床皮质醇增多症的治疗选择、糖尿病和骨质疏松症患者中亚临床皮质醇增多症的筛选、肾上腺网状带大结节增生、以及嗜铬细胞瘤／副神经节瘤基因的筛查等。

This article reviews the major advances of basal and clinical research on the adrenal diseases at home and abroad from 2010 to 2012. There are many advances including the diagnostic value of steroidogenic factor-1 in adrenal tumors, the pathogenesis and new diagnostic methods of aldosterone-producing adenoma, the treatment for severe ACTH-dependent Cushing＇s syndrome, approach to the patient with an adrenal incidentaloma and subclinical hypercortisolism, screening test for subclinical hypercortisolism in the patients with diabetes or osteoporosis, the characterization of macronodular adrenocortical hyperplasia of the zona reticularis, as well as genetic testing for pheochromocytoma and paragangliomas, etc.