摘要
目的：研究碱性成纤维细胞生长因子（ｂＦＧＦ）对硬腭穿孔愈合的影响。方法：在大鼠硬腭部制作 早期硬腭穿孔动物模型，外用ｂＦＧＦ治疗硬腭穿孔。采用肉眼观察、病理学检查的方法进行评价。结果：肉眼观 察发现ｂＦＧＦ组伤口愈合率明显高于对照组（Ｐ＜０．０１）；病理学检查表明ｂＦＧＦ能刺激肉芽组织的增长，成纤维 细胞分裂增殖；ｂＦＧＦ组成纤维细胞的核仁形成区嗜银蛋白颗粒数目为３．７３±０．５２，对照组为２．１１±０．３１（Ｐ＜ ０．０５）。结论：ｂＦＧＦ有助于肉芽组织的生长，具有显著促进硬腭穿孔创伤愈合的作用，有助手硬腭穿孔的修复。
AIM: To study the influence of basic fibroblast growth factor(bFGF) on treating ed palatal perforation in rats. METHODS: bFGF was given to the early palatal perforation in rat. The granulation tissues in perforations were grossly and pathologically obserVed. RESULTS: The the of wound healing was significantly in- crease in the bFGF group (P<0.01 ). bFGF could obviously promote the proliferation of the granulation tissues and fibroblasts. The number of AgNORs granules in fibrablasts were 3 .73 ±0.52 in the buy group and 2. 11 ±0.31 in control group (P < 0.05). CONCLUSION: bFGF could promote the growth of granulation tissues and had a strong promotion on the wound healing in palatal perforation. It was helpful in repairing palatal perforation.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2000年第5期451-453,I000,共4页
Chinese Journal of Pathophysiology
