糖尿病大鼠主动脉的重建

REMODELING OF AORTA IN STZ-INDUCED DIABETIC RATS

目的 探讨糖尿病大动脉形态结构重建和功能重建的特征以及两者的内在联系。 方法 应用形态学、生物力学和计算机图像分析等方法 ,观察了糖尿病大鼠主动脉的几何形态、显微结构成分含量和在体顺应性。 结果 (1)糖尿病大鼠主动脉的结构重建以血管肥厚为特征 ,平滑肌细胞的生长出现最早 ,继而出现胶原纤维面积进行性增大和弹性纤维面积减小 ;(2 )糖尿病时主动脉的顺应性大小改变出现较早 ,随着病程呈进行性下降 ;(3)糖尿病大鼠主动脉的顺应性与血管壁的 C/ E值显著相关。 结论 糖尿病时长期的高血糖环境 ,引起主动脉壁胶原纤维堆积和 C/ E值增大 ,导致了血管生物力学特性的改变 ,而顺应性可作为监测糖尿病血管功能的一项敏感指标。

Objective\ To reveal morphological and biomechanical changes of the aorta and the morphological basis of vascular functional remodeling in strepozotocin\|induced diabetic rats. Methods Morphological and computer image processing methods were used to observe structural remodeling and compliance in vivo of aorta. Results (1)The aortic structural remodeling in the diabetic rats expresses as vascular hypertrophy. Prior to collagen increase and elastin decreases, which results in the C/E ratio increase by degrees, the vascular smooth muscle cells' growth appears.(2)During diabetes development the aortic compliance changes early and decreases progressively which related to C/E ratio significantly. Conclusion It is suggested that the increase of collagen and the decreases of elastin in the aorta causes the increase of C/E ratio, which results in the decrease of aortic compliance.