周剂量紫杉醇联合顺铂、氟尿嘧啶治疗晚期胃癌临床观察

Clinical Observation of Weekly Dose Paclitaxel Combined with Cisplatin plus Fluorouracil Chemotherapy in the Treatment of Advanced Gastric Cancer

目的观察周剂量紫杉醇(PTX)联合顺铂(PDD)、氟尿嘧啶(5-Fu)治疗晚期胃癌的疗效及安全性。方法 46例晚期胃癌患者应用周剂量PTX+5-Fu+PDD联合化疗,至少2周期后评价疗效及毒副反应。结果 46例患者中,CR 6例(13.0%),PR 26例(56.5%),SD 12例(26.1%),PD 2例(4.3%),有效率为69.5%,临床获益率为89.1%。毒副反应主要为白细胞减少、脱发和胃肠道反应。结论周剂量PTX联合PDD、5-Fu方案是一种治疗晚期胃癌疗效高、安全性好的方案。

Objective To observe the curative effect and security of weekly dose paclitaxel＇ （PTX） combined with cisplatin （PDD） plus fluorouracil （5-Fu） chemotherapy in the treatment of advanced gastric cancer. Methods The 46 cases of advanced gastric cancer received the weekly dose PTX ＋ PDD ＋ 5-Fu chemotherapy, the curative effect and toxicities were evaluated after 2 cycles of chemoth. Results Of 46 cases, CR was observed in the 6 cases （13.0%）, PR 26 cases（56.5% ）, SD 12 cases （26.1% ）, PD 2 cases （4.3%）, the effective rate was 69.5%, the clinical benefit late was 89.1%. The major toxicities： leukopenia, alopecia and gastrointestinal reaction. Con- clusion Weekly dose PTX combined with PDD plus 5-Fu chemotherapy is a high curative effect and fine securityregimen for advanced gastric cancer.