温州市更年期妇女认知功能相关影响因素分析

Study on the Influencing Factors of Cognitive Functions of Menopausal Females in Wenzhou

目的:了解更年期妇女认知功能相关影响因素。方法:对门诊更年期妇女进行问卷调查,包括成套神经心理学功能测验、更年期综合征Kupperman量表评分;放射免疫法测定更年期妇女和正常育龄期妇女雌性激素水平。数据采用t检验、直线相关及偏相关分析。结果:更年期妇女血清LH、FSH水平高于正常育龄行经妇女,血清E2水平低于正常育龄行经妇女,差异均具有统计学意义。更年期妇女雌二醇水平与连线测试B用时、连线测试A用时均呈负相关;偏相关分析显示,对受教育年限固定后,更年期妇女的年龄与知识、算术得分正相关。对年龄固定后,受教育年限与数字广度得分、逻辑记忆得分、视觉记忆得分呈正相关,受教育年限与Stroop彩色文字阅读(Stroop-C)用时、木块图得分、连线测试A、B用时以及威斯康辛分类(WSCT)总错误数、连续错误数呈负相关。结论:更年期妇女认知水平受雌二醇水平、教育水平、年龄等因素影响。

Objective ：To know about the influencing factors of the menopausal females＇s cognitive function.Methods： Questionnaire sur- vey was conducted among menopausal females receiving outpatient services.The questionnaire included a set of cognitive function test and Kup- perman Index.The serum estrogen level of menopausal females and normal childbearing women was detected by radioimnlunoassay.The data was analyzed by t-test, the linear correlation analysis and partial correlation analysis. Results：The menopausal females had higher level of FSH and LH than normal females but with lower level of E2,and the distinctions were statistically significant. Trail making test （TMT）-A total time and TMT-B total time had a negative correlation with the estradiol levels of the menopausal females. The results of partial correlation showed that, menopausal females with same education level had a positive correlation between age and their knowledge and arithmetic score;menopausal fe- males with same age showed a positive correlation between education and their digital span,loglcal memory, visual memory, while education had a negative correlation with Stroop-C total time, block diagram score,TMT-A,TMT-B total time,WSCT total response error and repeated re- sponse error. Conclusion：The cognition function of menopausal female was affected by estradiol level,education and age.