血浆B型尿钠肽与急性肺栓塞预后相关性的研究

Study on correlation between B-type natriuretic peptide and prognosis of acute pulmonary embolism

目的探讨BNP和急性肺栓塞预后的相关性。方法所有确诊为急性肺栓塞的患者入院6 h内均定量检测血浆BNP水平,评估患者发生临床不良事件(死亡、休克、心肺复苏、气管插管及使用静脉升压药)与BNP的关系。结果98例患者中,BNP升高的有56例(57.1%),在BNP升高的患者中,发生休克、低氧血症、接受心肺复苏、使用静脉升压药以及死亡率较BNP正常水平组显著升高(P<0.05)。Kaplan-Meier法进行生存分析显示,血浆BNP水平<226.5 ng/L的急性肺栓塞患者的生存率明显高于血浆BNP水平>226.5 ng/L的患者(P=0.000)。结论血浆B型尿钠肽与急性肺栓塞预后密切相关。

Objective To investigate the associativity of prognostic value of B-type natriuretic peptide （BNP） and acute pulmonary embolism （APE）. Methods The plasma level of BNP of the patients with acute pulmonary embolism were mea- sured in 6 hours after admission to evaluate the relationship between the clinical adverse outcomes （death, shock cardiopul- monary resuscitation, tracheal intubation and vein pressor agent） and BNP. Results In all the 98 patients,56 （57.1%） pa- tients had the level of BNP above the upper limit of normal,of those 56 patients, the incidence rate of shock, hyoxemia, cardiopulmonary resuscitation and vein pressor agentand death rate were obviously higher than those BNP normal group （P 〈 0.05）. Kaplan-Meier survival analysis showed that the survival rate of patients whose blood plasma BNP level less than 226.5 ng/L was significantly higher than those patients whose blood plasma BNP level more than 226.5 ng/L （P = 0.000）. Conclusion B-type natriuretic peptide is closely associated with prognosis of acute pulmonary embolism.